Background：The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.
仕様
Synonyms：DNA repair protein RAD50,hRAD50,hsRAD50,Mrell,NBSLD,Rad 50,RAD50 2,rad50,RAD50 homolog （S cerevisiae）,RAD50 homolog,RAD50 PEN,RAD50,S. cerevisiae,homolog of,RAD50,RAD502,Rad50l,Truncated RAD50 protein
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IP
Concentration：1mg/ml
Immunogen：A synthetic peptide of human RAD50
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000 IP1：20 - 1：50
Gene_ID（human）：10111
Swissprot：Q92878
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling
