Background：The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin （an adipocyte-specific hormone that regulates body weight）, and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene （GeneID：54741） share the same promoter and the first 2 exons, however, encode distinct proteins （PMID：9207021）.
仕様
Synonyms：CD 295,CD295,CD295 antigen,Db,Fa,HuB219,LEP R,LEP-R,LEPR,LEPR,LEPRD,Leptin receptor,Leptin receptor fatty,Leptin receptor gene related protein,Leptin receptor precursor,Leptin receptor precursor,OB R gene related protein,OB receptor,OB-R,OB-RGRP,obl,Obr
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB
Concentration：1mg/ml
Immunogen：A synthetic peptide of human LEPR
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB 1：500 - 1：1000
Gene_ID（human）：3953
Swissprot：P48357
Isotype：IgG
Research Areas：Cancer, Cardiovascular, Metabolism, Signal transduction
