Background：Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intronless gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares aa sequence similarity with a putative apoptosis-related protein found in rat.
仕様
Synonyms：C7orf1,Claudin-3,Claudin3,CLD3,CLDN 3,Cldn3,Clostridium perfringens enterotoxin receptor 2,CPE R2,CPE receptor 2,CPE-R 2,CPE-receptor 2,CPETR 2,CPETR2,HRVP 1,HRVP1,Rat ventral prostate 1 like protein,Rat ventral prostate.1 protein homolog,RVP1,Ventral prostate.1 like protein,Ventral prostate.1 protein homolog
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB,IHC
Concentration：1mg/ml
Immunogen：Recombinant protein of human CLDN3
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000 IHC1：100 - 1：200
Gene_ID（human）：1365
Swissprot：O15551
Isotype：IgG
Research Areas：Cancer, Metabolism, Signal transduction
