Background：This is a paternally expressed imprinted gene that is thought to have been derived from the Ty3/Gypsy family of retrotransposons. It contains two overlapping open reading frames, RF1 and RF2, and expresses two proteins： a shorter, gag-like protein （with a CCHC-type zinc finger domain） from RF1; and a longer, gag/pol-like fusion protein （with an additional aspartic protease motif） from RF1/RF2 by -1 translational frameshifting （-1 FS）. While -1 FS has been observed in RNA viruses and transposons in both prokaryotes and eukaryotes, this gene represents the first example of -1 FS in a eukaryotic cellular gene. This gene is highly conserved across mammalian species and retains the heptanucleotide （GGGAAAC） and pseudoknot elements required for -1 FS. It is expressed in adult and embryonic tissues （most notably in placenta） and reported to have a role in cell proliferation, differentiation and apoptosis. Overexpression of this gene has been associated with several malignancies, such as hepatocellular carcinoma and B-cell lymphocytic leukemia. Knockout mice lacking this gene showed early embryonic lethality with placental defects, indicating the importance of this gene in embryonic development. Additional isoforms resulting from alternatively spliced transcript variants, and use of upstream non-AUG （CUG） start codon have been reported for this gene.
仕様
Synonyms：AA407948,Edr,Embryonal carcinoma differentiation regulated,Embryonal carcinoma differentiation-regulated protein,HB 1,HB1,KIAA1051,Mammalian retrotransposon-derived protein 2,Mar2,Mart2,MEF3 like 1,MEF3-like protein 1,MEF3L,MEF3L1,MyEF 3,Myelin expression factor 3-like protein 1,Paternally expressed 10,Paternally expressed gene 10 ORF1,Paternally expressed gene 10 protein,Peg10,PEG10 protein,PEG10,Putative uncharacterized protein PEG10,Retrotransposon gag domain containing 3,Retrotransposon gag domain-containing protein 3,Retrotransposon-derived gag-like polyprotein,Retrotransposon-derived protein PEG10,RGAG3,Ty3/Gypsy-like protein
Host：Rabbit
Reactivity：Human
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human PEG10
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：200 - 1：2000
Gene_ID（human）：23089
Swissprot：Q86TG7
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling, Stem cells
