Background：This gene encodes a scaffold protein that regulates the JNK （c-Jun N-terminal kinase） and NOD2 （nucleotide-binding oligomerization domain-containing protein 2） signaling pathways. The encoded protein interacts with another related JNK pathway scaffold protein, WDR62, via a conserved dimerization domain, and enhances JNK signaling. This protein may play a role in bacterial immunity by binding to the NOD2 receptor and negatively regulating downstream antibacterial and pro-inflammatory signaling. Mutations in this gene that impair cellular localization of the encoded protein cause a form of nephronophthisis, an autosomal-recessive kidney disorder, in human patients.
仕様
Synonyms：JNK binding protein 1,JNK-binding protein 1,JNKBP-1,JNKBP1,KIAA0596,MABP1,MAPKBP 1,mapkbp1,Mitogen activated protein kinase binding protein 1,Mitogen-activated protein kinase-binding protein 1
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC
Concentration：1mg/ml
Immunogen：A synthetic peptide of human MAPKBP1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
