Background：This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein （GAP）-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.
仕様
Synonyms：Acetate kinase 1,Acetokinase 1,ACK 1,ACK,ACK-1,ACK1,ACK1,Activated Cdc42 associated kinase 1,Activated CDC42 kinase 1,Activated p21cdc42Hs kinase,FLJ44758,FLJ45547,p21cdc42Hs,TNK 2,TNK2,Tyrosine kinase non receptor 2,Tyrosine kinase non receptor protein 2,Tyrosine kinase non-receptor protein 2
Host：Rabbit
Reactivity：Human
Applications：WB,IF
Concentration：1mg/ml
Immunogen：Recombinant protein of human TNK2
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000 IF1：50 - 1：200
Gene_ID（human）：10188
Swissprot：Q07912
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling, Signal transduction
