Background：This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants.
仕様
Synonyms：cancer/testis antigen 96,CT96,Dual specificity protein kinase TTK,ECSTY kinase,ESK,FLJ38280,hMPS1,Monopolar Spindle 1 Like 1 ,MPH1,Mps 1,MPS1L1,Phosphotyrosine Picked Threonine Kinase,Phosphotyrosine picked threonine-protein kinase,PYT,RP3-357D13.2,ttk,TTK Protein Kinase,TTK
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human TTK
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000
Gene_ID（human）：7272
Swissprot：P33981
Isotype：IgG
Research Areas：Cancer, Cell Biology, Epigenetics and Nuclear Signaling
