Background：This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12.
仕様
Synonyms：Ac2-121,AL022808,E3 ubiquitin-protein ligase UHRF1,EC 6.3.2.-,FLJ21925,hNP95,hUHRF1,HuNp95,ICBP90,Inverted CCAAT box binding protein of 90 kDa,Inverted CCAAT box binding protein,90-kD,Inverted CCAAT box-binding protein of 90 kDa,Liver regeneration-related protein LRRG126,MGC138707,NP95,Nuclear phosphoprotein 95,Nuclear phosphoprotein,95-KD,Nuclear protein 95,Nuclear zinc finger protein Np95,RING finger protein 106,RNF106,TDRD22,Transcription factor ICBP90,Ubiquitin like containing PHD and RING finger domains protein 1,Ubiquitin like PHD and RING finger domain containing protein 1,Ubiquitin-like PHD and RING finger domain-containing protein 1,Ubiquitin-like protein containing PHD and RING finger domains 1,Ubiquitin-like with PHD and ring finger domains 1,Ubiquitin-like,containing PHD and RING finger domains,1,Ubiquitin-like-containing PHD and RING finger domains protein 1,UHRF1,UHRF1
Host：Rabbit
Reactivity：Human
Applications：WB,IHC,IF
Concentration：1mg/ml
Immunogen：Recombinant protein of human UHRF1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
