Background：This gene encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described.
仕様
Synonyms：DKFZp686L09142,DMAP 1,DNA methyltransferase 1 associated protein 1,DNMAP 1,DNMAP1,DNMT1 associated protein 1,DNMTAP 1,DNMTAP1,EAF 2,EAF2,FLJ11543,KIAA1425,MAT 1 mediated transcriptional repressor,MGC55593,SWC 4,SWC4,zgc：55593
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC
Concentration：1mg/ml
Immunogen：Recombinant protein of human DMAP1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：1000 - 1：4000 IHC1：50 - 1：200
Gene_ID（human）：55929
Swissprot：Q9NPF5
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling
