Background：The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor （HIF） alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Mutations in this gene are associated with erythrocytosis familial type 3 （ECYT3）.
仕様
Synonyms：C1ORF12,Chromosome 1 Open Reading Frame 12,DKFZp761F179,ECYT 3,ECYT3,Egl 9 family hypoxia inducible factor 1,EGL 9 homolog of C. elegans 1,EGL nine （C.elegans） homolog 1,Egl nine homolog 1 （C. elegans）,Egl nine homolog 1,Egl nine like protein 1,EGLN 1,Egln1,EGLN1,HIF PH2,HIF Prolyl Hydroxylase 2,HIF-PH2,HIF-prolyl hydroxylase 2,HIFP4H 2,HIFPH2,HPH 2,HPH-2,HPH2,Hypoxia inducible factor prolyl hydroxylase 2,Hypoxia-inducible factor prolyl hydroxylase 2,ORF13,P4H2,PHD 2,PhD2,PNAS 118,PNAS 137,Prolyl Hydroxylase Domain Containing Protein 2,Prolyl hydroxylase domain-containing protein 2,Rat Homolog of SM20,SM 20,SM-20,SM20,Zinc finger MYND domain containing protein 6,ZMYND6
Host：Rabbit
Reactivity：Human
Applications：IF
Concentration：1mg/ml
Immunogen：Recombinant protein of human EGLN1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：IF1：50 - 1：200
Gene_ID（human）：54583
Swissprot：Q9GZT9
Isotype：IgG
Research Areas：Cancer, Cardiovascular, Epigenetics and Nuclear Signaling, Metabolism
