Background：DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. This gene belongs to a family of nuclear proteins which are characterized by the presence of a methyl-CpG binding domain （MBD）. The encoded protein is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. Unlike the other family members, the encoded protein is not capable of binding to methylated DNA. The protein mediates the association of metastasis-associated protein 2 with the core histone deacetylase complex. Alternative splicing results in multiple transcript variants of this gene.
仕様
Synonyms：AI181826,AU019209,MBD 3,Mbd3,MBD3： methyl CpG binding domain protein 3,MBD3,Methyl CpG binding domain protein 3,Methyl CpG binding protein MBD3,Methyl-CpG-binding domain protein 3,Methyl-CpG-binding protein MBD3
Host：Rabbit
Reactivity：Human
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human MBD3
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：200 - 1：2000
Gene_ID（human）：53615
Swissprot：O95983
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling
