Background：This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor （TCR） stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.
仕様
Synonyms：70 kDa zeta associated protein,70 kDa zeta-associated protein,EC 2.7.10.2,FLJ17670,FLJ17679,Selective T cell defect,SRK,STD,Syk related tyrosine kinase,Syk-related tyrosine kinase,Truncated ZAP kinase,Tyrosine protein kinase ZAP70,Tyrosine-protein kinase ZAP-70,TZK,ZAP 70,ZAP70,ZAP70,Zeta chain associated protein kinase 70kD,Zeta chain associated protein kinase 70kDa,Zeta chain associated protein kinase 70kDa isoform 1,Zeta chain associated protein kinase 70kDa isoform 2,Zeta chain of T cell receptor associated protein kinase 70,Zeta chain TCR associated protein kinase 70kD,Zeta chain TCR associated protein kinase 70kDa
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB,IHC
Concentration：1mg/ml
Immunogen：Recombinant protein of human ZAP70
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Dilution：WB1：500 - 1：2000 IHC1：50 - 1：200
Gene_ID（human）：7535
Swissprot：P43403
Isotype：IgG
Research Areas：Cancer, Immunology, Signal transduction, Tags ＆ Cell Markers
