Background：This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding different proteins.
仕様
Synonyms：1 25 dihydroxyvitamin D3 receptor,1,1,25 dihydroxyvitamin D3 receptor,1,25-@dihydroxyvitamin D3 receptor,25-dihydroxyvitamin D3 receptor,Member 1,NR1I1,Nuclear receptor subfamily 1 group I member 1,PPP1R163,Protein phosphatase 1,regulatory subunit 163,VDR,VDR,Vitamin D （1,25- dihydroxyvitamin D3） receptor,Vitamin D hormone receptor,Vitamin D nuclear receptor variant 1,Vitamin D receptor,Vitamin D3 receptor
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human VDR
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB 1：500 - 1：2000
Gene_ID（human）：7421
Swissprot：P11473
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling, Signal transduction
