Background：This gene encodes a secreted serine protease that converts plasminogen to plasmin. The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond to form the catalytically inactive high molecular weight urokinase-type plasminogen activator （HMW-uPA）. HMW-uPA can be further processed into the catalytically active low molecular weight urokinase-type plasminogen activator （LMW-uPA）. This low molecular weight form does not bind to the urokinase-type plasminogen activator receptor. Mutations in this gene may be associated with Quebec platelet disorder and late-onset Alzheimer's disease. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
仕様
Synonyms：ATF,ATF uPA,BDPLT5,Plasminogen activator,Plasminogen activator urinary,Plasminogen activator urokinase,PLAU,QPD,u PA,U plasminogen activator,u-PA,U-plasminogen activator,uPA,URK,UROK,Urokinase plasminogen activator,Urokinase type plasminogen activator,Urokinase type plasminogen activator precursor,Urokinase-type plasminogen activator chain B
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human PLAU
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000
Gene_ID（human）：5328
Swissprot：P00749
Isotype：IgG
Research Areas：Cancer, Cardiovascular, Metabolism, Neuroscience
