Background：HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha （DQA） and a beta chain （DQB）, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells （APC： B Lymphocytes, dendritic cells, macrophages）. The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation.
仕様
Synonyms：CD,CELIAC1,DC 1 alpha chain,DC alpha,DC-1 alpha chain,DC-alpha,DC1,included,DQ alpha 1 chain,DQ-A1,DQ-DRW9 alpha chain,DQA1,FLJ27088,FLJ27328,Gluten-sensitive enteropathy （celiac disease）,GSE,HLA class II histocompatibility antigen,HLA class II histocompatibility antigen,DQ alpha 1 chain,HLA class II histocompatibility antigen,DQ（W3） alpha chain,HLA-DCA,HLA-DQA,HLA-DQA1,HLA-DQA1 major histocompatibility complex,class II,DQ alpha 1,HLADC histocompatibility type,Immune response antigens HIa,included,leucocyte antigen DQA1,leukocyte antigen alpha chain,LOC100133678,LOC100507686,LOC100509457,Major histocompatibility complex,class II,DQ alpha 1,MGC149527,MHC class II antigen,MHC class II DQA1,MHC class II HLA-D alpha glycoprotein,MHC class II HLA-DQ alpha 1,MHC class II surface glycoprotein,MHC HLA-DQ alpha,OTTHUMP00000029141,OTTHUMP00000176885,OTTHUMP00000178551,OTTHUMP00000178552,OTTHUMP00000233817
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB,IHC
Concentration：1mg/ml
Immunogen：Recombinant protein of human HLA-DQA1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
