Background：The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals and are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon.
仕様
Synonyms：c Jun kinase 3,c-Jun N-terminal kinase 3,cJun N terminal kinase 3,FLJ12099,FLJ33785,JNK3 alpha protein kinase,JNK3,JNK3A,MAP kinase 10,MAP kinase,MAP kinase p49 3F12,MAPK 10,Mapk10,MGC50974,mitogen activated protein kinase 10,Mitogen-activated protein kinase 10,MK10,p493F12,p54bSAPK,PRKM10,protein kinase mitogen activated 10,SAPK1b,Stress activated protein kinase 1b,stress activated protein kinase beta,Stress activated protein kinase JNK3,Stress-activated protein kinase JNK3
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human MAPK10
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000
Gene_ID（human）：5602
Swissprot：P53779
Isotype：IgG
Research Areas：Cancer, Neuroscience, Signal transduction
