Background：The Fanconi anemia complementation group （FANC） currently includes FANCA, FANCB, FANCC, FANCD1 （also called BRCA2）, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ （also called BRIP1）, FANCL, FANCM and FANCN （also called PALB2）. The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group D2. This protein is monoubiquinated in response to DNA damage, resulting in its localization to nuclear foci with other proteins （BRCA1 AND BRCA2） involved in homology-directed DNA repair. Alternative splicing results in multiple transcript variants.
仕様
Synonyms：DKFZp762A223,FA 4,FA D2,FA4,FAC D2,FACD 2,FACD,FACD2,FACD2,FAD,FAD2,FANC D2,FANCD 2,FANCD,FANCD2,FANCONI ANEMIA COMPLEMENTATION GROUP D,Fanconi anemia complementation group D2,Fanconi anemia group D2 protein,FANCONI PANCYTOPENIA TYPE 4,FLJ23826,OTTHUMP00000158853,OTTHUMP00000207925,Protein FACD2,Type 4 Fanconi pancytopenia
Host：Rabbit
Reactivity：Human
Applications：WB,IF
Concentration：1mg/ml
Immunogen：Recombinant protein of human FANCD2
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000 IF1：50 - 1：200
Gene_ID（human）：2177
Swissprot：Q9BXW9
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling
