Background：The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains： the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy （Kennedy disease）. Mutations in this gene are also associated with complete androgen insensitivity （CAIS）. Two alternatively spliced variants encoding distinct isoforms have been described.
仕様
Synonyms：AIS,ANDR,Androgen nuclear receptor variant 2,Androgen receptor （dihydrotestosterone receptor,testicular feminization,spinal and bulbar muscular atrophy,Kennedy disease）,Androgen receptor,androgen receptor splice variant 4b,AR,AR8,DHTR,Dihydro testosterone receptor,Dihydrotestosterone receptor （DHTR）,Dihydrotestosterone receptor,HUMARA,HYSP1,KD,Kennedy disease （KD）,NR3C4,Nuclear receptor subfamily 3 group C member 4 （NR3C4）,Nuclear receptor subfamily 3 group C member 4,SBMA,SMAX1,Spinal and bulbar muscular atrophy （SBMA）,Spinal and bulbar muscular atrophy,Testicular Feminization （TFM）,TFM
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB,IHC
Concentration：1mg/ml
Immunogen：A synthetic peptide of human AR
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Dilution：WB1：500 - 1：2000 IHC1：50 - 1：100
Gene_ID（human）：367
Swissprot：P10275
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling, Developmental biology, Signal transduction
