Background：This gene encodes the protein elongin C, which is a subunit of the transcription factor B （SIII） complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been identified.
仕様
Synonyms：Elongin C,Transcription Elongation Factor B （SIII）, Polypeptide 1 （15kDa, Elongin C）,RNA Polymerase II Transcription Factor SIII Subunit C,Transcription Elongation Factor B Polypeptide 1,Transcription Elongation Factor B Subunit 1,Elongin 15 KDa Subunit,SIII P15.
