Background：This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta （TGF-beta） superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene.
仕様
Synonyms：Activin A receptor type IIA,Activin receptor type 2A,Activin receptor type IIA,Activin receptor type-2A,ACTR 2,ACTR IIA,ACTR-IIA,ACTR2,ACTRII,ACTRIIA,Acvr 2,Acvr 2A,Acvr2,ACVR2A,AVR2A,OTTHUMP00000197918
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC
Concentration：1mg/ml
Immunogen：Recombinant protein of human ACVR2A
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB 1：500 - 1：2000 IHC 1：100 - 1：200
Gene_ID（human）：92
Swissprot：P27037
Isotype：IgG
Research Areas：Cancer, Metabolism, Signal transduction, Stem cells
