Background：This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene.
仕様
Synonyms：CAR,CAR BETA,CAR1,CARA,Constitutive activator of retinoid response,constitutive active receptor,Constitutive active response,constitutive androstane nuclear receptor variant 2,constitutive androstane nuclear receptor variant 3,constitutive androstane nuclear receptor variant 4,constitutive androstane nuclear receptor variant 5,Constitutive androstane receptor,MB67,MGC97144,NR1I3,NR1I3,Nuclear receptor subfamily 1 group I member 3,orphan nuclear hormone receptor,Orphan nuclear receptor MB67,Orphan nuclear receptor NR1I3
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IF
Concentration：1mg/ml
Immunogen：Recombinant protein of human NR1I3
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000 IF1：50 - 1：200
Gene_ID（human）：9970
Swissprot：Q14994
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling, Metabolism, Signal transduction
