Background：This gene encodes the class A macrophage scavenger receptors, which include three different types （1, 2, 3） generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins （LDLs）. The isoform type 3 does not internalize modified LDL （acetyl-LDL） despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.
仕様
Synonyms：CD204,CD204 antigen,CD24,Macrophage acetylated LDL receptor I and II,Macrophage scavenger receptor 1,Macrophage scavenger receptor type III,Macrophage scavenger receptor types I and II,Msr 1,MSR1,MSRE,phSR1,phSR2,SCARA 1,SCARA1,Scavenger receptor class A member 1,Scavenger receptor class A,member 1,Scavenger receptor type A,Scvr,SR A,SRA
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human MSR1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB 1：500 - 1：2000
Gene_ID（human）：4481
Swissprot：P21757
Isotype：IgG
Research Areas：Cancer, Cardiovascular, Metabolism, Immunology
