Background：This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development. Alternatively spliced transcript variants encoding distinct isoforms have been described.
仕様
Synonyms：Paired Like Homeodomain 2,Paired-Like Homeodomain Transcription Factor 2,ALL1-Responsive Protein ARP1,Homeobox Protein PITX2,Solurshin,RIEG1,ARP1,RIEG,RGS,Rieg Bicoid-Related Homeobox Transcription Factor 1,RIEG Bicoid-Related Homeobox Transcription Factor,Paired-Like Homeodomain 2,All1-Responsive Gene 1.
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB
Concentration：1mg/ml
Immunogen：A synthetic peptide of human PITX2
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
