Background：This gene encodes a member of the ATP-dependent DNA ligase protein family. The encoded protein functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Disruption of this gene may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants.
仕様
Synonyms：DNA ligase 1,DNA ligase I,DNLI1,LIG 1,lig1,Ligase I DNA ATP dependent,MGC117397,MGC130025,Polydeoxyribonucleotide synthase [ATP] 1
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB,IF
Concentration：1mg/ml
Immunogen：Recombinant protein of human LIG1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB 1：500 - 1：2000 IF 1：50 - 1：200
Gene_ID（human）：3978
Swissprot：P18858
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling
