Background：This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia （ALL）.
仕様
Synonyms：CLL associated antigen KW 6,DNA-binding protein Ikaros,hIk 1,Hs.54452,IK1,Ikaros （zinc finger protein）,IKAROS,IKAROS family zinc finger 1 （Ikaros）,Ikaros family zinc finger protein 1,Ikzf1,IKZF1,LYF1,Lymphoid transcription factor LyF-1,PRO0758,Zinc finger protein subfamily 1A 1 （Ikaros）,Zinc finger protein subfamily 1A 1,Zinc finger protein, subfamily 1A, member 1,ZNFN1A1
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IF
Concentration：1mg/ml
Immunogen：Recombinant protein of human IKZF1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000 IF1：50 - 1：200
Gene_ID（human）：10320
Swissprot：Q13422
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling
