Background：This gene encodes the pulmonary-associated surfactant protein C （SPC）, an extremely hydrophobic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90％ lipids and 10％ proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 2, also called pulmonary alveolar proteinosis due to surfactant protein C deficiency, and are associated with interstitial lung disease in older infants, children, and adults. Alternatively spliced transcript variants encoding different protein isoforms have been identified.
仕様
Synonyms：BRICD6,BRICHOS domain containing 6,PSP C,PSPC,PSPC,Pulmonary surfactant apoprotein 2,Pulmonary surfactant apoprotein PSP C,pulmonary surfactant apoprotein-2 SP-C,Pulmonary surfactant associated protein C,Pulmonary surfactant associated proteolipid SPL pVal,Pulmonary surfactant associated proteolipid SPL（Val）,Pulmonary surfactant protein SP5,Pulmonary surfactant-associated protein C,Pulmonary surfactant-associated proteolipid SPL（Val）,SFTP 2,SFTP2,SFTPC,SFTPC surfactant pulmonary associated protein C,SMDP2,SP 5,SP C,SP-C,SP5,SPC,Surfactant associated protein pulmonary 2,Surfactant protein c,Surfactant proteolipid SPL-pVal,Surfactant pulmonary associated protein C
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC
Concentration：1mg/ml
Immunogen：Recombinant protein of human SFTPC
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000 IHC1：50 - 1：200
Gene_ID（human）：6440
Swissprot：P11686
Isotype：IgG
Research Areas：Cancer, Cardiovascular, Metabolism, Signal transduction
