Background：This gene encodes a member of the hydroxymethylbilane synthase superfamily. The encoded protein is the third enzyme of the heme biosynthetic pathway and catalyzes the head to tail condensation of four porphobilinogen molecules into the linear hydroxymethylbilane. Mutations in this gene are associated with the autosomal dominant disease acute intermittent porphyria. Alternatively spliced transcript variants encoding different isoforms have been described.
仕様
Synonyms：HEM3,HMBS,Hydroxymethylbilane synthase,PBG D,PBG-D,PBGD,PORC,Porphobilinogen deaminase,porphyria,acute,Chester type,Pre uroporphyrinogen synthase,Pre-uroporphyrinogen synthase,UPS,Uroporphyrinogen I synthase,Uroporphyrinogen I synthetase
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human HMBS
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000
Gene_ID（human）：3145
Swissprot：P08397
Isotype：IgG
Research Areas：Cancer, Cell Biology, Metabolism, Signal transduction
