Background：This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs （SKP1-cullin-F-box）, which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes： Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA （nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha）, targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6.
仕様
Synonyms：Beta transducin repeat containing E3 ubiquitin protein ligase,beta TrCP1,beta-transducin repeat containing ,BETA-TRCP,betaTrCP,btrC,bTrCP,bTrCP1,E3RSIkappaB,F box and WD repeat protein 1B,F box and WD repeats protein beta TrCP,F-box and WD repeats protein beta-TrCP,F-box/WD repeat protein 1A,F-box/WD repeat-containing protein 1A,FBW1A,FBW1A,FBXW1,FBXW1A,FWD1,HOS,mKIAA4123,pIkappaBalpha-E3 receptor subunit,Slimb
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human BTRC
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Dilution：WB 1：500 - 1：2000
Gene_ID（human）：8945
Swissprot：Q9Y297
Isotype：IgG
Research Areas：Cancer, Cell Biology, Microbiology, Neuroscience
