Background：The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.
仕様
Synonyms：AHUS2,Antigen defined by monoclonal TRA 2 10,Antigen identified by monoclonal TRA 2 10,CD46,CD46 antigen,CD46 antigen complement regulatory protein,CD46 molecule,CD46 molecule complement regulatory protein,Complement membrane cofactor protein,MCP,MCP,Measles virus receptor,membrane cofactor protein （CD46,trophoblast-lymphocyte cross-reactive antigen）,Membrane cofactor protein,MGC26544,MIC10,TLX,TRA2.10,Trophoblast leucocyte common antigen,Trophoblast leukocyte common antigen,Trophoblast lymphocyte cross reactive antigen
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human CD46
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
