Background：Cytochrome b （-245） is composed of cytochrome b alpha （CYBA） and beta （CYBB） chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease （CGD）. In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole.
仕様
Synonyms：AMCBX2,CGD,CGD91-phox,CY24B,CYBB,Cytochrome b 245,beta polypeptide,Cytochrome b（558） beta chain,Cytochrome b（558） subunit beta,Cytochrome b-245 heavy chain,Cytochrome b558 subunit beta,GP91 PHOX,gp91-1,gp91-phox,GP91PHOX,Heme-binding membrane glycoprotein gp91phox,NADPH oxidase 2,Neutrophil cytochrome b 91 kDa polypeptide,NOX2,p22 phagocyte B-cytochrome,P91 PHOX,p91-PHOX,Superoxide-generating NADPH oxidase heavy chain subunit
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC
Concentration：1mg/ml
Immunogen：A synthetic peptide of human CYBB
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
