Background：The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette （ABC） transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies （ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White）. This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules.
仕様
Synonyms：ABC transporter,MHC 2,ABC18,ABCB3,Antigen peptide transporter 2,APT2,ATP binding cassette,sub family B （MDR/TAP）,member 3,ATP-binding cassette sub-family B member 3,D6S217E,Peptide supply factor 2,Peptide transporter involved in antigen processing 2,Peptide transporter PSF2,Peptide transporter TAP2,PSF 2,PSF-2,PSF2,Really interesting new gene 11 protein,RING 11,RING11,TAP 2,Tap2,TAP2,Transporter 2 ATP binding cassette sub family B,Transporter 2,ABC （ATP binding cassette,Transporter 2,ATP binding cassette,sub family B （MDR/TAP）
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IF
Concentration：1mg/ml
Immunogen：Recombinant protein of human TAP2
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
