Background：The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components： a preexisting cytosolic component that translocates to the nucleus upon T cell receptor （TCR） stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes.
仕様
Synonyms：cytoplasmic 1,MGC138448,NF ATc,NF ATc1,NF-ATc,NF-ATc1,NF-ATc1.2,NFAC1,NFAT 2,NFAT transcription complex cytosolic component,NFATC 1,NFATc,NFATc1,Nuclear factor of activated T cells cytoplasmic 1,Nuclear factor of activated T cells cytoplasmic calcineurin dependent 1,Nuclear factor of activated T cells cytosolic component 1,nuclear factor of activated T-cells 'c',Nuclear factor of activated T-cells
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human NFATC1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000
Gene_ID（human）：4772
Swissprot：O95644
Isotype：IgG
Research Areas：Cancer, Cardiovascular, Epigenetics and Nuclear Signaling, Immunology, Signal transduction
