Background：This gene encodes a protein that is essential for nonsense-mediated mRNA decay （NMD）; a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
仕様
Synonyms：breast cancer-associated antigen SGA-56M,C1orf16,EST1 like protein C,EST1 telomerase component homolog C,EST1-like protein C,EST1C,ever shorter telomeres 1C,FLJ23717,hSMG-7,nonsense mediated mRNA decay factor （C. elegans）,Protein SMG7,SGA56M,SMG 7,SMG-7 homolog,Smg7,SMG7
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human SMG7
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
