Background：cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum （ER）.
仕様
Synonyms：cAMP dependent protein kinase regulatory subunit alpha 2,cAMP dependent protein kinase regulatory subunit RII alpha,cAMP dependent protein kinase type II alpha regulatory chain,cAMP dependent protein kinase type II alpha regulatory subunit,cAMP-dependent protein kinase type II-alpha regulatory subunit,KAP2,KAP2,MGC3606,PKR 2,PKR2,PRKA R2,PRKAR 2,PRKAR2,PRKAR2A,Protein kinase A RII alpha subunit,Protein kinase cAMP dependent regulatory type II alpha
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human PRKAR2A
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：1000 - 1：2000
Gene_ID（human）：5576
Swissprot：P13861
Isotype：IgG
Research Areas：Cancer, Metabolism, Signal transduction
