Background：The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme （RNAseH2）. RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes. Mutations in this gene cause Aicardi-Goutieres Syndrome （AGS）, a an autosomal recessive neurological disorder characterized by progressive microcephaly and psychomotor retardation, intracranial calcifications, elevated levels of interferon-alpha and white blood cells in the cerebrospinal fluid.
仕様
Synonyms：AGS4 ,Aicardi Goutieres syndrome 4 protein,EC 3.1.26.4,JUNB,Ribonuclease HI large subunit,Ribonuclease HI subunit A,RNase H（35）,RNase H2 subunit A,RNase HI large subunit,RNASEH2A,RNASEHI,RNHIA,RNHL
Host：Rabbit
Reactivity：Rat
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human RNASEH2A
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
