Background:This gene encodes a poly(A) binding protein. The protein shuttles between the nucleus and cytoplasm and binds to the 3' poly(A) tail of eukaryotic messenger RNAs via RNA-recognition motifs. The binding of this protein to poly(A) promotes ribosome recruitment and translation initiation; it is also required for poly(A) shortening which is the first step in mRNA decay. The gene is part of a small gene family including three protein-coding genes and several pseudogenes.
仕様
Synonyms:PAB 1,PAB1,PABP 1,PABP1,PABPC 1,PABPC1,PABPC2,PABPL1,Poly A binding protein 1,Poly A binding protein cytoplasmic 1,poly(A) binding protein,cytoplasmic 1,poly(A) binding protein,cytoplasmic 2,Polyadenylate binding protein 1
Host:Rabbit
Reactivity:Human,Mouse,Rat
Applications:WB
Concentration:1mg/ml
Immunogen:A synthetic peptide of human PABPC1
Purification Method:Affinity purification
Clonality:Polyclonal
Conjugation:Unconjugated
Buffer:Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Dilution:WB1:500 - 1:2000
Gene_ID(human):26986
Swissprot:P11940
Isotype:IgG
Research Areas:Cancer, Epigenetics and Nuclear Signaling