Background：The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette （ABC） transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies （ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White）. This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants.
仕様
Synonyms：ABC20,ABCB1,ATP binding cassette,sub family B （MDR/TAP）,member 1,ATP-binding cassette sub-family B member 1,CD243,CLCS,Colchicin sensitivity,Doxorubicin resistance,GP170,MDR1,MDR1,Multidrug resistance 1,Multidrug resistance protein 1,P glycoprotein 1,P gp,P-glycoprotein 1,PGY1
Host：Rabbit
Reactivity：Mouse,Rat
Applications：WB,IHC
Concentration：1mg/ml
Immunogen：A synthetic peptide of human ABCB1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide,50％ glycerol,pH7.3.
Dilution：WB1：500 - 1：2000 IHC1：50 - 1：200
Gene_ID（human）：5243
Swissprot：P08183
Isotype：IgG
Research Areas：Cancer, Metabolism, Signal transduction, Stem cells
