Background：This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains： an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene （GeneID 10332; often referred to as L-SIGN）. DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.
仕様
Synonyms：C type lectin domain family 4 member L,C-type lectin domain family 4 member L,CD 209,CD209,CD209 antigen,CD209 antigen-like protein A,CD209 molecule,CD209,Cd209a,CDSIGN,CIRE,CLEC4L,DC SIGN,DC SIGN1,DC-SIGN,DC-SIGN1,DCSIGN,Dendritic cell specific ICAM 3 grabbing nonintegrin 1,Dendritic cell specific ICAM3 grabbing nonintegrin 1,Dendritic cell-specific ICAM-3-grabbing non-integrin 1,Dendritic cell-specific intracellular adhesion molecules （ICAM）-3 grabbing non-integrin,Dengue fever,protection against,included,Dentritic Cell Specific ICAM3 Grabbing Nonintegrin,HIV GP120 Binding Protein,MGC129965,MGC130443,SIGN-R1,SIGNR5
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human CD209
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：200 - 1：500
Gene_ID（human）：30835
Swissprot：Q9NNX6
Isotype：IgG
Research Areas：Cancer, Immunology, Microbiology, Signal transduction
