Background：This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories： type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.
仕様
Synonyms：bA525O21.1 （coagulation factor XIII,A1 polypeptide）,Coagulation factor XIII A chain,Coagulation factor XIII A1 polypeptide,Coagulation factor XIII A1 subunit,Coagulation factor XIII,A polypeptide,Coagulation factor XIIIa,F13A,F13A,F13a1,Factor XIIIA,Fibrin stabilizing factor,A subunit,Fibrinoligase,FSF,A subunit,Protein glutamine gamma glutamyltransferase A chain,Protein-glutamine gamma-glutamyltransferase A chain,TGase,Transglutaminase A chain,Transglutaminase,plasma,Transglutaminase. plasma
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human F13A1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000
Gene_ID（human）：2162
Swissprot：P00488
Isotype：IgG
Research Areas：Cancer, Cardiovascular, Tags ＆ Cell Markers
