Background：The nucleotide excision repair pathway is a mechanism to repair damage to DNA. The protein encoded by this gene is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. The gene product has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
仕様
Synonyms：TFIIH 80 kDa subunit,Basic transcription factor 2 80 kDa subunit,BTF2 p80,COFS 2,COFS2,CXPD,DNA excision repair protein ERCC 2,DNA excision repair protein ERCC-2,DNA repair protein complementing XP D cells,DNA repair protein complementing XP-D cells,EM9,ERCC 2,ERCC2,ERCC2,Excision repair 2,Excision repair cross complementing rodent repair deficiency complementation,Excision repair cross complementing rodent repair deficiency, complementation group 2,MAG,MGC102762,MGC126218,MGC126219,OTTHUMP00000045860,OTTHUMP00000045861,OTTHUMP00000045862,OTTHUMP00000045863,TFIIH 80 kDa subunit,TFIIH basal transcription factor complex 80 kDa subunit,TFIIH Basal Transcription Factor Complex Helicase Subunit,TFIIH basal transcription factor complex helicase XPD subunit,TFIIH basal transcription factor complex p80 subunit,TFIIH p80,TTD,Xeroderma pigmentosum complementary group D,Xeroderma pigmentosum group D complementing protein,Xeroderma pigmentosum group D-complementing protein,XPD,XPDC
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human ERCC2
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000
Gene_ID（human）：2068
Swissprot：P18074
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling
