Background：The protein encoded by this gene is a member of the protein tyrosine phosphatase （PTP） family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog （SH2） domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported.
仕様
Synonyms：70Z-SHP,EC 3.1.3.48,HCP,HCPH,Hematopoietic cell phosphatase,Hematopoietic cell protein tyrosine phosphatase,Hematopoietic cell protein-tyrosine phosphatase,HPTP1C,Protein tyrosine phosphatase 1C,Protein tyrosine phosphatase non receptor type 6,Protein tyrosine phosphatase SHP1,Protein-tyrosine phosphatase 1C,protein-tyrosine phosphatase SHP 1,Protein-tyrosine phosphatase SHP-1,PTN6,PTP 1C,PTP-1C,PTP1C,Ptpn6,SH PTP 1,SH PTP1,SH-PTP1,SHP 1,SHP 1L,SHP1,SHP1L,tyrosine protein phosphatase non receptor type 6,Tyrosine-protein phosphatase non-receptor type 6
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB,IF
Concentration：1mg/ml
Immunogen：Recombinant protein of human PTPN6
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000 IF1：50 - 1：200
Gene_ID（human）：5777
Swissprot：P29350
Isotype：IgG
Research Areas：Cancer, Cell Biology, Developmental biology, Signal transduction
