Background：This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 （H3K4） methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.
仕様
Synonyms：ALL-1,ALL1,C-terminal cleavage product of 180 kDa,CXXC-type zinc finger protein 7,CXXC7,HRX,HTRX1,KMT2A,Lysine N-methyltransferase 2A,Mll,MLL cleavage product C180,MLL1,MLL1,MLL1A,N-terminal cleavage product of 320 kDa,p180,p320,Trithorax-like protein,TRX1,Zinc finger protein HRX
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant Protein of human KMT2A
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000
Gene_ID（human）：4297
Swissprot：Q03164
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling
