Background：This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized.
仕様
Synonyms：AAT3,FAA3,LDS1B,LDS2,LDS2B,MFS2,RIIC,TAAD2,TbetaR II,TbetaR-II,TGF beta receptor type 2,TGF beta receptor type II,TGF beta receptor type IIB,TGF beta type II receptor,TGF-beta receptor type II,TGF-beta receptor type-2,TGF-beta type II receptor,TGF-beta-R2,TGFB R2,TGFbeta - RII,TGFbeta RII,Tgfbr2,TGFR-2,TGFR2,Transforming growth factor beta receptor II,Transforming growth factor beta receptor type II,Transforming growth factor beta receptor type IIC,Transforming growth factor,beta receptor II （70/80kDa）,transforming growth factor,beta receptor II alpha,transforming growth factor,beta receptor II beta,transforming growth factor,beta receptor II delta,transforming growth factor,beta receptor II epsilon,transforming growth factor,beta receptor II gamma,Transforming growth factor-beta receptor type II
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human TGFBR2
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Dilution：WB1：500 - 1：2000
Gene_ID（human）：7048
Swissprot：P37173
Isotype：IgG
Research Areas：Cancer, Signal transduction, Stem cells
