Background：This gene encodes a member of the nuclear distribution E （NudE） family of proteins. The encoded protein is localized at the centrosome and interacts with other centrosome components as part of a multiprotein complex that regulates dynein function. This protein plays an essential role in microtubule organization, mitosis and neuronal migration. Mutations in this gene cause lissencephaly 4, a disorder characterized by lissencephaly, severe brain atrophy, microcephaly, and severe mental retardation. Alternative splicing results in multiple transcript variants.
仕様
Synonyms：FLJ20101,HOM TES 87,LIS1 interacting protein NUDE1 rat homolog,LIS1 interacting protein NUDE1,LIS4,NDE 1,NDE1,NDE1,Nuclear distribution gene E homolog 1,Nuclear distribution protein nudE homolog 1,NUDE 1,NudE,NudE nuclear distribution gene E homolog 1 （A. nidulans） ,NudE nuclear distribution gene E homolog 1,NUDE1
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human NDE1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Dilution：WB 1：500 - 1：2000
Gene_ID（human）：54820
Swissprot：Q9NXR1
Isotype：IgG
Research Areas：Cell Biology, Epigenetics and Nuclear Signaling, Neuroscience
