Background：This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene.
仕様
Synonyms：FLJ35621,FLJ37491,NAD dependent deacetylase sirtuin 2,NAD-dependent deacetylase sirtuin-2,NAD-dependent protein deacetylase sirtuin-2,Regulatory protein SIR2 homolog 2,Silencing information regulator 2 like,Silent information regulator 2,SIR2,SIR2 like protein 2,Sir2 related protein type 2,SIR2,S. cerevisiae,homolog-loke 2,SIR2-like protein 2,SIR2L,SIR2L2,SIRT2,SIRT2,Sirtuin （silent mating type information regulation 2 homolog） 2 （S.cerevisiae）,Sirtuin 2,Sirtuin type 2
Host：Rabbit
Reactivity：Mouse,Rat
Applications：WB
Concentration：1mg/ml
Immunogen：A synthetic peptide of human SIRT2
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000
Gene_ID（human）：22933
Swissprot：Q8IXJ6
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling, Signal transduction
