Background：Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family （GRIPS） contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants.
仕様
Synonyms：DGSX,Glypican proteoglycan 3,Glypican-3 [Precursor],Gpc3,GPC3,GTR2 2,GTR2-2,Heparan sulphate proteoglycan,Intestinal protein OCI 5,Intestinal protein OCI-5,MXR7,OCI 5,OCI-5,OCI5,SDYS,Secreted glypican-3,SGB,SGBS,SGBS1
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human GPC3
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000
Gene_ID（human）：2719
Swissprot：P51654
Isotype：IgG
Research Areas：Cancer, Developmental biology, Signal transduction, Stem cells
