Background：The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C （RFC）, which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. Alternative splicing results in multiple transcript variants.
仕様
Synonyms：Checkpoint protein HUS1,hHUS1,HUS1 （S. pombe） checkpoint homolog,Hus1,HUS1 checkpoint homolog （S. pombe）,HUS1 Checkpoint Protein,HUS1 protein,HUS1+ - like protein,HUS1,Hydroxyurea-sensitive 1, S. pombe, homolog of
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC
Concentration：1mg/ml
Immunogen：Recombinant protein of human HUS1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000 IHC1：50 - 1：200
Gene_ID（human）：3364
Swissprot：O60921
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling
