Background：The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene.
仕様
Synonyms：2310016J22Rik,4921524A02Rik,AI507642,AU021743,AW551584,C430041B13Rik,LIM and senescent cell antigen like domains 1,LIM and senescent cell antigen-like-containing domain protein 1,LIM zinc finger domain containing 1,LIM-type zinc finger domains 1,Lims1,LIMS1,Lims1l,Particularly interesting new Cys His protein 1,Particularly interesting new Cys His protein,Particularly interesting new Cys-His protein 1,PINCH 1,PINCH,PINCH-1,PINCH1,Renal carcinoma antigen NY REN 48,Renal carcinoma antigen NY-REN-48,senescent cell antigen,wu：fc32c03,zgc：112533
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB,IF
Concentration：1mg/ml
Immunogen：Recombinant protein of human LIMS1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000 IF1：50 - 1：100
Gene_ID（human）：3987
Swissprot：P48059
Isotype：IgG
Research Areas：Cancer, Cardiovascular, Signal transduction
