Background：This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported.
仕様
Synonyms：CTHBP,Cytosolic thyroid hormone binding protein,Cytosolic thyroid hormone-binding protein,KPYM,MGC3932,OIP 3,OIP-3,OIP3,OPA interacting protein 3,Opa-interacting protein 3,p58,PK muscle type,PK,muscle type,PK2,PK3,PKM,PKM2,pykm,Pyruvate kinase 2/3,Pyruvate kinase 3,Pyruvate kinase isozymes M1/M2,Pyruvate kinase muscle,Pyruvate kinase muscle isozyme,pyruvate kinase PKM,Pyruvate kinase,muscle 2,TCB,THBP1,Thyroid hormone binding protein 1,Thyroid hormone binding protein cytosolic,Thyroid hormone-binding protein 1,Tumor M2 PK,Tumor M2-PK
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human PKM
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
Dilution：WB1：500 - 1：2000
Gene_ID（human）：5315
Swissprot：P14618
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling, Metabolism, Signal transduction
