Background：This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants.
仕様
Synonyms：HLA class I antigen,FLJ36918,FLJ60820,MGC111087,MGC21250,MHC class I chain related gene A protein,MHC class I chain related protein A,MHC class I chain related protein A HLA B HLA C,MHC class I polypeptide related sequence A,MHC class I polypeptide-related sequence A,MHC class I related protein,MIC A,MIC-A,micA,MICA,OTTHUMP00000029088,OTTHUMP00000044528,OTTHUMP00000165170,OTTHUMP00000165172,PERB11.1,Stress inducible class I homolog
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB
Concentration：1mg/ml
Immunogen：Recombinant protein of human MICA
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：Buffer： PBS with 0.02％ sodium azide, 50％ glycerol, pH7.3.
